Long non-coding RNA MIR22HG inhibits the adipogenesis of human bone marrow mesenchymal stem cells with the involvement of Wnt/β-catenin pathway
نویسندگان
چکیده
Osteoporosis is a frequently occurring bone remodeling disorder worldwide with one characteristic being decreasing mineral density and predisposition to fracture, which diminishes patients’ quality of life. Several studies showed that imbalance between the osteogenesis adipogenesis marrow mesenchymal stem cells (BMSCs) took part in development osteoporosis. In previous study, we found MIR22HG regulated human BMSCs positively. this was decreased during exerted negative effects on involvement Wnt/β-catenin signaling pathway both vitro vivo. Nitazoxanide could inhibit Wnt relieve MIR22HG’s suppression adipogenesis. These findings indicated had great potential clinical application for osteoporosis treatment prevention.
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ژورنال
عنوان ژورنال: Biocell
سال: 2022
ISSN: ['0327-9545', '1667-5746']
DOI: https://doi.org/10.32604/biocell.2022.018706